The T4 Glycoprotein Is a Cell-surface Receptor for the AIDS Virus
- J.S. McDougal*,
- P.J. Maddon**,
- A.G. Dalgleish†,
- P.R. Clapham‡,
- D.R. Littman‡‡,
- M. Godfrey††,
- D.E. Maddon‡‡,
- L. Chess††,
- R.A. Weiss‡, and
- R. Axel‡‡
- *Immunology Branch, Centers for Disease Control, Atlanta, Georgia 30333
- †Clinical Research Centre, Northwick Park Hospital, Harrow, England HA1 3UJ
- ‡Institute of Cancer Research, Chester Beatty Laboratories, London, England SW3 6JB
- **Department of Biochemistry and Molecular Biophysics, ††Department of Medicine, and ‡‡Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York 10032
This extract was created in the absence of an abstract.
Excerpt
Peripheral T lymphocytes recognize foreign antigen in association with major histocompatibility complex (MHC) gene products on the surface of target cells (Zinkernagel and Doherty 1979). The recognition of diverse foreign antigens requires that at least one component of the T-cell surface be highly polymorphic. This recognition function is carried out by the T-cell antigen receptor. The T lymphocyte, however, expresses other nonpolymorphic surface proteins that have been implicated in the mediation of efficient T-cell-target cell interactions. Analysis of the surface proteins of peripheral T lymphocytes demonstrates that mature T cells segregate into one of two classes: those that express the surface glycoprotein T4 and those that express the glycoprotein T8 (Reinherz and Schlossman 1980). The T4 molecule is primarily expressed on helper T lymphocytes whereas T8 is expressed on cytotoxic and suppressor cells (Thomas et al. 1981; Meuer et al. 1982). A more stringent relationship exists between these T-cell subsets...
