A Structural Guide to Proteins of the NF-κB Signaling Module
- 1Department of Chemistry and Biochemistry, San Diego State University, 5500 Campanile Drive, San Diego, California 92182-1030
- 2Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0375
- Correspondence: gghosh{at}ucsd.edu
Abstract
The prosurvival transcription factor NF-κB specifically binds promoter DNA to activate target gene expression. NF-κB is regulated through interactions with IκB inhibitor proteins. Active proteolysis of these IκB proteins is, in turn, under the control of the IκB kinase complex (IKK). Together, these three molecules form the NF-κB signaling module. Studies aimed at characterizing the molecular mechanisms of NF-κB, IκB, and IKK in terms of their three-dimensional structures have lead to a greater understanding of this vital transcription factor system.
Footnotes
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Editors: Louis M. Staudt and Michael Karin
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Additional Perspectives on NF-κB available at www.cshperspectives.org
- Copyright © 2009 Cold Spring Harbor Laboratory Press; all rights reserved
