RNA Processing and Export
- 1Department for Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461
- 2Department of Bionanoscience, Delft University of Technology
- Correspondence: rhsinger{at}aecom.yu.edu
Abstract
Messenger RNAs undergo 5' capping, splicing, 3'-end processing, and export before translation in the cytoplasm. It has become clear that these mRNA processing events are tightly coupled and have a profound effect on the fate of the resulting transcript. This processing is represented by modifications of the pre-mRNA and loading of various protein factors. The sum of protein factors that stay with the mRNA as a result of processing is modified over the life of the transcript, conferring significant regulation to its expression.
Footnotes
-
Editors: Tom Misteli and David L. Spector
-
Additional Perspectives on The Nucleus available at www.cshperspectives.org
- Copyright © 2010 Cold Spring Harbor Laboratory Press; all rights reserved
