The Golgin Coiled-Coil Proteins of the Golgi Apparatus

  1. Sean Munro
  1. MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom
  1. Correspondence: sean{at}mrc-lmb.cam.ac.uk

Abstract

A number of long coiled-coil proteins are present on the Golgi. Often referred to as “golgins,” they are well conserved in evolution and at least five are likely to have been present in the last common ancestor of all eukaryotes. Individual golgins are found in different parts of the Golgi stack, and they are typically anchored to the membrane at their carboxyl termini by a transmembrane domain or by binding a small GTPase. They appear to have roles in membrane traffic and Golgi structure, but their precise function is in most cases unclear. Many have binding sites for Rab family GTPases along their length, and this has led to the suggestion that the golgins act collectively to form a tentacular matrix that surrounds the Golgi to capture Rab-coated membranes in the vicinity of the stack. Such a collective role might explain the lack of cell lethality seen following loss of some of the genes in human familial conditions or mouse models.



Also in this Collection

      | Table of Contents

      This Article

      1. Cold Spring Harb. Perspect. Biol. 3: a005256 Copyright © 2011 Cold Spring Harbor Laboratory Press; all rights reserved

      Article Category

      Updates/Comments

      1. Submit Updates/Comments
      2. No Updates/Comments published

      Subject Collections

      1. The Golgi

      Share

      In this Collection