A new ‘Linc’ between noncoding RNAs and blood development
- 1Division of Hematology/Oncology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;
- 2Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Abstract
Long noncoding RNAs (lncRNAs) are a large and diverse class of functional RNAs that regulate important biological processes, including cell division, survival, and differentiation. In this issue of Genes & Development, Hu and colleagues (2573–2578) report the discovery of LincRNA erythroid prosurvival (LincRNA-EPS), a murine lncRNA that facilitates red blood cell formation (erythropoiesis) by suppressing apoptosis. This finding expands the repertoire of lncRNA functions and illustrates a novel genetic pathway that potentially can be exploited for treating anemias.
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Footnotes
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↵3 Corresponding author.
E-mail weissmi{at}email.chop.edu.
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.183020.111.
- Copyright © 2011 by Cold Spring Harbor Laboratory Press
