HARPing on about the DNA damage response during replication

  1. Robert Driscoll and
  2. Karlene A. Cimprich1
  1. Department of Chemical and Systems Biology, Stanford University, Stanford, California 94305, USA

    Abstract

    In this issue of Genes & Development, four papers report that the annealing helicase HepA-related protein (HARP, also known as SMARCAL1 [SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a-like 1]) binds directly to the ssDNA-binding protein Replication protein A (RPA) and is recruited to sites of replicative stress. Knockdown of HARP results in hypersensitivity to multiple DNA-damaging agents and defects in fork stability or restart. These exciting insights reveal a key new player in the S-phase DNA damage response.

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    1. doi: 10.1101/gad.1860609 Genes & Dev. 23: 2359-2365 Copyright © 2009 by Cold Spring Harbor Laboratory Press

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