Inactivation of the anterior cingulate cortex blocks expression of remote, but not recent, conditioned taste aversion memory
- 1 Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto M5G 1X8, Canada;
- 2 Department of Physiology, University of Toronto, Toronto M5S 1A8, Canada;
- 3 Graduate Program in Areas of Basic and Applied Biology (GABBA), Universidade do Porto, 4050-465 Porto, Portugal;
- 4 Institute of Medical Science, University of Toronto, Toronto M5S 1A8, Canada
Abstract
Previous studies have shown that medial prefrontal cortical regions, such as the anterior cingulate cortex (ACC), play a key role in the expression of remote spatial and contextual memory. To evaluate whether this role is conserved in hippocampal-independent tasks we trained mice in the conditioned taste aversion (CTA) paradigm. Lidocaine-induced inactivation of the ACC blocked the expression of CTA tested one month (remote), but not one day (recent), after conditioning with either a weak or strong unconditioned stimulus (US). These data suggest that the ACC may play a conserved role in remote memory, regardless of memory strength or content.
Footnotes
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↵5 Corresponding author.
↵5 E-mail paul.frankland{at}sickkids.ca; fax (416) 813-7177.
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Article is online at http://www.learnmem.org/cgi/doi/10.1101/lm.905008.
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- Received January 13, 2008.
- Accepted February 21, 2008.
- Copyright © 2008, Cold Spring Harbor Laboratory Press
