Transport of point-size Brownian particles under the influence of a constant and uniform force field through a planar three-dimensional channel with smoothly varying, axis-symmetric periodic side walls is investigated. Here we employ an asymptotic analysis in the ratio between the difference of the widest and the most narrow constriction divided through the period length of the channel geometry. We demonstrate that the leading-order term is equivalent to the Fick-Jacobs approximation. By use of the higher-order corrections to the probability density we show that in the diffusion-dominated regime the average transport velocity is obtained as the product of the zeroth-order Fick-Jacobs result and the expectation value of the spatially dependent diffusion coefficient $D(x)$, which substitutes the constant diffusion coefficient in the common Fick-Jacobs equation. The analytic findings are corroborated with the precise numerical results of a finite element calculation of the Smoluchowski diffusive particle dynamics occurring in a reflection symmetric sinusoidal-shaped channel.

• Received 24 February 2011

DOI:https://doi.org/10.1103/PhysRevE.83.051135