Panax ginseng Extract Improves the Performance of Aged Fischer 344 Rats in Radial Maze Task but Not in Operant Brightness Discrimination Task

Hiroyuki NITTA; Kinzo MATSUMOTO; Mineo SHIMIZU; XiaoHu NI; Hiroshi WATANABE

doi:10.1248/bpb.18.1286

Hiroyuki NITTA, Kinzo MATSUMOTO, Mineo SHIMIZU, XiaoHu NI, Hiroshi WATANABE

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Keywords: Panax ginseng, aged rat, spatial cognition, radial maze task, operant bright discrimination task

JOURNAL FREE ACCESS

1995 Volume 18 Issue 9 Pages 1286-1288

DOI https://doi.org/10.1248/bpb.18.1286

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Abstract

The effect of Panax ginseng extract on the learning performance of aged Fischer 344 rats using the 8-arm radial maze task and the operant discrimination task was examined. Aged rats showed significantly impaired learning performance in both tasks. Daily administration of ginseng extract (8g/kg/d, p. o. for 12-33 d) ameliorated the impairment of learning performance in the radial maze task but not in the operant discrimination task. These results suggest that subchronic treatment with ginseng extract improves spatial cognitive impairment in aged rats.

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