Antinociceptive Profile of 2-Phenylselenenyl-1,8-cineole in Mice

Damião Pergentino de Sousa; Ellen Raphael; Ursula Brocksom; Timothy John Brocksom

doi:10.1248/bpb.27.910

Notes

Antinociceptive Profile of 2-Phenylselenenyl-1,8-cineole in Mice

Damião Pergentino de Sousa, Ellen Raphael, Ursula Brocksom, Timothy John Brocksom

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Keywords: antinociceptive, terpene, 1,8-cineole, phenylselenenyl

JOURNAL FREE ACCESS

2004 Volume 27 Issue 6 Pages 910-911

DOI https://doi.org/10.1248/bpb.27.910

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Abstract

2-Phenylselenenyl-1,8-cineole (PSC) increased both the pentobarbital-induced sleeping time and the reaction time (up to 2 h) in the tail immersion method. PSC also caused dose-dependent inhibition of acetic acid induced writhing with maximum inhibition of 93.4% and was approximately 8.5-fold more potent than 1,8-cineole. These findings show that PSC presents sedative effect and significant antinociceptive activity.

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