Fusogenic Liposome can be Used as an Effective Vaccine Carrier for Peptide Vaccination to Induce Cytotoxic T Lymphocyte (CTL) Response

Toshiki Sugita; Tomoaki Yoshikawa; Jian-Qing Gao; Mariko Shimokawa; Atushi Oda; Takako Niwa; Mitsuru Akashi; Yasuo Tsutsumi; Tadanori Mayumi; Shinsaku Nakagawa

doi:10.1248/bpb.28.192

Notes

Fusogenic Liposome can be Used as an Effective Vaccine Carrier for Peptide Vaccination to Induce Cytotoxic T Lymphocyte (CTL) Response

Toshiki Sugita, Tomoaki Yoshikawa, Jian-Qing Gao, Mariko Shimokawa, Atushi Oda, Takako Niwa, Mitsuru Akashi, Yasuo Tsutsumi, Tadanori Mayumi, Shinsaku Nakagawa

Author information

Toshiki Sugita
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University
CREST (Core Research for Evolutional Science and Technology) of Japan Science and Technology Corporation
Tomoaki Yoshikawa
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University
CREST (Core Research for Evolutional Science and Technology) of Japan Science and Technology Corporation
Jian-Qing Gao
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University
Mariko Shimokawa
CREST (Core Research for Evolutional Science and Technology) of Japan Science and Technology Corporation
Atushi Oda
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University
CREST (Core Research for Evolutional Science and Technology) of Japan Science and Technology Corporation
Takako Niwa
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University
CREST (Core Research for Evolutional Science and Technology) of Japan Science and Technology Corporation
Mitsuru Akashi
Department of Molecular Chemistry, Graduate School of Engineering, Osaka University
CREST (Core Research for Evolutional Science and Technology) of Japan Science and Technology Corporation
Yasuo Tsutsumi
Osaka Branch Fundamental Research Laboratories for Development of Medicine, National Institute of Health Science, Japan
CREST (Core Research for Evolutional Science and Technology) of Japan Science and Technology Corporation
Tadanori Mayumi
Department of Cell Therapeutics, Graduate School of Pharmaceutical Sciences, Kobe-Gakuin University
Shinsaku Nakagawa
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University
CREST (Core Research for Evolutional Science and Technology) of Japan Science and Technology Corporation

Keywords: fusogenic liposome, cytotoxic T lymphocyte (CTL), peptide vaccine

JOURNAL FREE ACCESS

2005 Volume 28 Issue 1 Pages 192-193

DOI https://doi.org/10.1248/bpb.28.192

Details

Abstract

We reported previously that fusogenic liposome (FL) introduced antigen protein encapsulated in the liposome directly into the cytoplasm of the antigen presenting cells, and that it induced immune responses. In the present study, we encapsulated TAX38-46, an HTLV-I derived protein and an antigen peptide model, into FL. The ability to induce effective cytotoxic T lymphocytes (CTL) responses in immunized mice was evaluated. Results showed FL could induce CTL response effectively and suggested that FL is a potential peptide vaccine carrier.

Corresponding author

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