A new lignan 1 and two phenolic compounds, scopoletin and vanillic acid, were isolated from the stems of Trachelospermum asiaticum NAKAI var. intermedium NAKAI (Apocynaceae). The structure of 1 was elucidated as (2R, 3R) 2-4"-hydroxy-3"-methoxybenzyl-3-3', 4', 5'-trimethoxybenzylbutyrolactone by analysis of the carbon-13 nuclear magnetic resonance, mass and circular dichroism spectra.