New Sesterterpenes with Nerve Growth Factor Synthesis-Stimulating Activity from the Okinawan Marine Sponge Hyrtios sp.

Yukiko DOI; Hideyuki SHIGEMORI; Masami ISHIBASHI; Fumio MIZOBE; Akira KAWASHIMA; Shiro NAKAIKE; Jun'ichi KOBAYASHI

doi:10.1248/cpb.41.2190

Yukiko DOI, Hideyuki SHIGEMORI, Masami ISHIBASHI, Fumio MIZOBE, Akira KAWASHIMA, Shiro NAKAIKE, Jun'ichi KOBAYASHI

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Keywords: sesterterpene, nerve growth factor, sponge, 12-O-desacetylfuroscalarol, 12-O-desacetylscalarin, Hyrtios sp.

JOURNAL FREE ACCESS

1993 Volume 41 Issue 12 Pages 2190-2191

DOI https://doi.org/10.1248/cpb.41.2190

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Abstract

Two new pentacyclic sesterpenes, 12-O-desacetylfuroscalarol (1) and 12-O-desacetylscalarin (2), which enhance nerve growth factor synthesis, have been isolated from the Okinawan marine sponge Hyrtios sp. and their structures elucidated on the basis of spectroscopic data.

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