Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Constituents of Sindora sumatrana MIQ.I. Isolation and NMR Spectral Analysis of Sesquiterpenes from the Dried Pods
Henry HEYMANNYasuhiro TEZUKATohru KIKUCHISutardjo SUPRIYATNA
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1994 Volume 42 Issue 1 Pages 138-146

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Abstract

Investigation of the neutral fraction of the dried pods of Sindora sumatrana MIQ. has resulted in the isolation of three new sesquiterpenoids (2, 6 and 8) together with nine known ones (1, 3, 4, 5, 7, 9, 10, 11a and 12a), of which three (7, 10 and 12a) are reported for the first time from a natural source. One other compound, 4-stigmasten-3-one (13) (together with a sterol mixture; β-sitosterol, stigmasterol and campesterol) was also obtained. The structures of all the isolated sesquiterpenes were determined by means of spectroscopic methods, mainly two-dimensional NMR techniques, and the compounds were found to have the caryophyllane, humulane, clovane and caryolane skeletons. The NMR data of the isolated sesquiterpenes are also discussed.

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© The Pharmaceutical Society of Japan
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