Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
New Hydrolyzable Tannins, Shephagenins A and B, from Shepherdia argentea as HIV-1 Reverse Transcriptase Inhibitors
Takashi YOSHIDA, Hideyuki ITO, Tsutomu HATANO, Mari KURATA, Tsutomu NAKANISHI, Akira INADA, Hiroko MURATA, Yuka INATOMI, Nobuyasu MATSUURA, Katsuhiko ONO, Hideo NAKANE, Miho NODA, Frank A. LANG, Jin MURATA
Author information
Keywords: Shepherdia argentea, Elaeagnaceae, shephagenin A, shephagenin B, HIV-1 reverse transcriptase
JOURNAL FREE ACCESS

1996 Volume 44 Issue 8 Pages 1436-1439

Details
Download PDF (693K)
Download citation RIS

(compatible with EndNote, Reference Manager, ProCite, RefWorks)

BIB TEX

(compatible with BibDesk, LaTeX)

Text
How to download citation
Contact us
Abstract

Two new hydrolyzable tannins, shephagenins A and B, were isolated along with hippophaenin A and strictinin from the leaf extract of Shepherdia argentea, which showed a remarkable inhibitory activity against human immunodeficiency virus (HIV)-1 reverse transcriptase. Their structures, having a gluconic acid core, have been elucidated on the basis of spectroscopic and chemical methods. The inhibitory effect of the leaf extract on HIV-1 reverse transcriptase was found to be due to tannins, and their activities were stronger than that of (-)-epigallocatechin gallate as a positive control.

Content from these authors
© The Pharmaceutical Society of Japan
Previous article Next article
Favorites & Alerts

Recently viewed articles
Share this page
feedback
 Top