Cytotoxic Principles of a Bangladeshi Crude Drug, Akond Mul (Roots of Calotropis gigantea L.)

Fumiyuki KIUCHI; Yumi FUKAO; Takuro MARUYAMA; Tohru OBATA; Motohiro TANAKA; Takuma SASAKI; Masayuki MIKAGE; Mohammad Ekramul HAQUE; Yoshisuke TSUDA

doi:10.1248/cpb.46.528

Fumiyuki KIUCHI, Yumi FUKAO, Takuro MARUYAMA, Tohru OBATA, Motohiro TANAKA, Takuma SASAKI, Masayuki MIKAGE, Mohammad Ekramul HAQUE, Yoshisuke TSUDA

Author information

Fumiyuki KIUCHI
Yumi FUKAO
Takuro MARUYAMA
Tohru OBATA
Motohiro TANAKA
Takuma SASAKI
Masayuki MIKAGE
Mohammad Ekramul HAQUE
Yoshisuke TSUDA
Author's Organization：
Faculty of Pharmaceutical Sciences, Kanazawa University
Faculty of Pharmaceutical Sciences, Kanazawa University
Faculty of Pharmaceutical Sciences, Kanazawa University
Cancer Research Institute, Kanazawa University
Cancer Research Institute, Kanazawa University
Cancer Research Institute, Kanazawa University
Faculty of Pharmaceutical Sciences, Kanazawa University
Department of Pharmacy, Rajshahi University
Faculty of Pharmaceutical Sciences, Kanazawa University

Keywords: Calotropis gigantea, cytotoxicity, cardenolide, calotropin, frugoside, Asclepiadaceae

JOURNAL FREE ACCESS

1998 Volume 46 Issue 3 Pages 528-530

DOI https://doi.org/10.1248/cpb.46.528

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Abstract

Three cardenolide glycosides, calotropin (1), frugoside (2), and 4'-O-β-D-glucopyranosylfrugoside (3), were obtained as the cytotoxic principles of "akond mul" (roots of Calotropis gigantea L.). The cytotoxicity of these compounds against various cell lines of human and mouse origin was tested. They showed similar cell line selectivity to those of cardiac glycosides such as digoxin and ouabain : they are toxic to cell lines of human origin, but not to those from mouse at 2μg/ml.

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