Pyrinodemins B-D, Potent Cytotoxic bis-Pyridine Alkaloids from Marine Sponge Amphimedon sp.

Keiko HIRANO; Takaaki KUBOTA; Masashi TSUDA; Yuzuru MIKAMI; Jun'ichi KOBAYASHI

doi:10.1248/cpb.48.974

Keiko HIRANO, Takaaki KUBOTA, Masashi TSUDA, Yuzuru MIKAMI, Jun'ichi KOBAYASHI

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Keywords: sponge, Amphimedon sp., bis-pyridine alkaloids, cytotoxicity, antimicrobial activity

JOURNAL FREE ACCESS

2000 Volume 48 Issue 7 Pages 974-977

DOI https://doi.org/10.1248/cpb.48.974

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Abstract

New bis-pyridine alkaloids, pyrinodemins B-D (1-3), have been isolated together with pyrinodemin A (4) and related 3-alkyl pyridine alkaloids 5-8 from the Okinawan marine sponge Amphimedon sp. and the structures were elucidated from spectroscopic data. Pyrinodemins B-D (1-3) showed potent cytotoxicity, while compounds 5-8 exhibited antimicrobial activity.

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