Two New Monoterpene Glycosides and Trypanocidal Terpenoids from Dracocephalum kotschyi

Soodabeh Saeidnia; Ahmad Reza Gohari; Nahoko Uchiyama; Michiho Ito; Gisho Honda; Fumiyuki Kiuchi

doi:10.1248/cpb.52.1249

Notes

Two New Monoterpene Glycosides and Trypanocidal Terpenoids from Dracocephalum kotschyi

Soodabeh Saeidnia, Ahmad Reza Gohari, Nahoko Uchiyama, Michiho Ito, Gisho Honda, Fumiyuki Kiuchi

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Keywords: Dracocephalum kotschyi, monoterpene glucoside, trypanocidal activity

JOURNAL FREE ACCESS

2004 Volume 52 Issue 10 Pages 1249-1250

DOI https://doi.org/10.1248/cpb.52.1249

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Abstract

From the whole plant of Dracocephalum kotschyi BOISS., two new monoterpene glycosides (9, 10), together with seven known terpenoids and a phytosterol (1—8), were isolated. Their structures were determined to be limonen-10-al (1), geranial (2), neral (3), β-sitosterol (4), oleanolic acid (5), ursolic acid (6), p-mentha-8-en-1,2-diol (7), colosolic acid (8), limonen-10-ol 10-O-β-D-glucopyranoside (9), and limonen-10-ol 10-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside (10). Compounds 1 (3.1 μM), 2 (3.1 μM), 3 (3.1 μM), 5 (6.2 μM), 6 (6.2 μM), and 8 (6.2 μM) were effective against epimastigotes of Trypanosoma cruzi.

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