Anti-plasmodial Activity of Some Constituents of the Root Bark of Harungana madagascariensis L<small>AM</small>. (Hypericaceae)

Bruno Ndjakou Lenta; Silvère Ngouela; Fabrice Fekam Boyom; Ferdinand Tantangmo; Guy Raymond Feuya Tchouya; Etienne Tsamo; Jiri Gut; Philip Jon Rosenthal; Joseph Donald Connolly

doi:10.1248/cpb.55.464

Notes

Anti-plasmodial Activity of Some Constituents of the Root Bark of Harungana madagascariensis LAM. (Hypericaceae)

Bruno Ndjakou Lenta, Silvère Ngouela, Fabrice Fekam Boyom, Ferdinand Tantangmo, Guy Raymond Feuya Tchouya, Etienne Tsamo, Jiri Gut, Philip Jon Rosenthal, Joseph Donald Connolly

Author information

Bruno Ndjakou Lenta
Department of Chemistry, Higher Teachers' Training College, University of Yaoundé 1
Silvère Ngouela
Department of Organic Chemistry, Faculty of Science, University of Yaoundé I
Fabrice Fekam Boyom
Department of Biochemistry, Faculty of Science, University of Yaoundé I
Ferdinand Tantangmo
Department of Organic Chemistry, Faculty of Science, University of Yaoundé I
Guy Raymond Feuya Tchouya
Department of Organic Chemistry, Faculty of Science, University of Yaoundé I
Etienne Tsamo
Department of Organic Chemistry, Faculty of Science, University of Yaoundé I
Jiri Gut
Division of Infectious Diseases, Department of Medicine, University of California
Philip Jon Rosenthal
Division of Infectious Diseases, Department of Medicine, University of California
Joseph Donald Connolly
Department of Chemistry, The University

Keywords: Harungana madagascariensis, Hypericaceae, anthrone, Plasmodium falciparum, anti-plasmodial

JOURNAL FREE ACCESS

2007 Volume 55 Issue 3 Pages 464-467

DOI https://doi.org/10.1248/cpb.55.464

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Abstract

Bazouanthrone (1), a new anthrone derivative, has been isolated from the root bark of Harungana madagascariensis, together with known compounds, feruginin A (2), harunganin (3), harunganol A (4), harunganol B (5), friedelan-3-one (6) and betulinic acid (7). The structure of the compound (1) was assigned as 3,5,8,9-tetrahydroxy-2,4,4-tri-(3,3-dimethylallyl)-6-methyl-1-(4H)-anthracenone, by means of spectroscopic analysis. The anti-plasmodial activity of the isolated compounds was evaluated in culture against W2 strain of Plasmodium falciparum. All the compounds were found to be active against the Plasmodium parasites with bazouanthrone (1) showing particular potency (IC₅₀=1.80 μM).

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