Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Electrochemical Oxidation of Luteolin at a Glassy Carbon Electrode and Its Application in Pharmaceutical Analysis
Ailin LiuShaobo ZhangLiying HuangYangyuan CaoHong YaoWei ChenXinhua Lin
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2008 Volume 56 Issue 6 Pages 745-748

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Abstract

Luteolin is a flavonoid reported to occur widely in many medicinal plants. The electrochemical behavior of luteolin was studied in phosphate buffer solution (PBS) of pH 4.0 at a glassy carbon electrode (GCE) by cyclic voltammetry (CV) and differential pulse voltammetric method (DPV). The results indicated the well-defined redox peak of luteolin which was involving two electrons and two protons was observed and the electrode process is adsorption-controlled. The charge transfer coefficient (α) was calculated as 0.66. The relationships between oxidation peak current and the concentration of luteolin are linear in the range of 1.0×10−8—1.0×10−6 M by DPV method. The detection limit had been estimated as 5.0×10−9 M. The facile and rapid method has been successfully applied to the detection of luteolin in tablets.

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© 2008 The Pharmaceutical Society of Japan
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