Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Oxygenated Cembranoids from the Cultured and Wild-Type Soft Corals Sinularia flexibilis
Jui-Hsin Su, Yu-Fang Lin, Yi Lu, Hsiao-Chien Yeh, Wei-Hsien Wang, Tung-Yung Fan, Jyh-Horng Sheu
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Keywords: cembranoid, Sinularia flexibilis, cytotoxicity
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2009 Volume 57 Issue 11 Pages 1189-1192

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Abstract

Two new cembranoids, flexibilisolide A (1) and flexibilisin A (2), along with one known combranoid 5 have been isolated from the cultured soft coral Sinularia flexibilis. Furthermore, two new cembranoids, flexibilisolide B (3) and flexibilisin B (4), along with two known combranoids (5, 6), have been isolated from the wild-type soft coral S. flexibilis. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis and by comparison of NMR data with those of known compounds. The metabolites 5 and 6 have been shown to exhibit weak cytotoxic activity against MCF-7 cancer cell line.

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© 2009 The Pharmaceutical Society of Japan
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