Cucurbitane Triterpenoids from Momordica charantia and Their Cytoprotective Activity in tert-Butyl Hydroperoxide-Induced Hepatotoxicity of HepG2 Cells

Chiy-Rong Chen; Yun-Wen Liao; Lai Wang; Yueh-Hsiung Kuo; Hung-Jen Liu; Wen-Ling Shih; Hsueh-Ling Cheng; Chi-I Chang

doi:10.1248/cpb.58.1639

Notes

Cucurbitane Triterpenoids from Momordica charantia and Their Cytoprotective Activity in tert-Butyl Hydroperoxide-Induced Hepatotoxicity of HepG2 Cells

Chiy-Rong Chen, Yun-Wen Liao, Lai Wang, Yueh-Hsiung Kuo, Hung-Jen Liu, Wen-Ling Shih, Hsueh-Ling Cheng, Chi-I Chang

Author information

Chiy-Rong Chen
Department of Biological Science and Technology, Meiho University
Yun-Wen Liao
Graduate Institute of Biotechnology, National Pingtung University of Science and Technology
Lai Wang
Graduate Institute of Biotechnology, National Pingtung University of Science and Technology
Yueh-Hsiung Kuo
Tsuzuki Institute for Traditional Medicine, College of Pharmacy, China Medical University
Hung-Jen Liu
Institute of Molecular Biology, National Chung-Hsing University
Wen-Ling Shih
Graduate Institute of Biotechnology, National Pingtung University of Science and Technology
Hsueh-Ling Cheng
Graduate Institute of Biotechnology, National Pingtung University of Science and Technology
Chi-I Chang
Graduate Institute of Biotechnology, National Pingtung University of Science and Technology

Keywords: Chinese herb, Momordica charantia, Cucurbitaceae, pentanorcucurbitane, trinorcucurbitane, cytoprotective

JOURNAL FREE ACCESS

2010 Volume 58 Issue 12 Pages 1639-1642

DOI https://doi.org/10.1248/cpb.58.1639

Details

Abstract

Two novel pentanorcucurbitane triterpenes, 22-hydroxy-23,24,25,26,27-pentanorcucurbit-5-en-3-one (1) and 3,7-dioxo-23,24,25,26,27-pentanorcucurbit-5-en-22-oic acid (2) together with a new trinorcucurbitane triterpene, 25,26,27-trinorcucurbit-5-ene-3,7,23-trione (3) were isolated from the methyl alcohol extract of the stems of Momordica charantia. The structures of the new compounds were elucidated by spectroscopic methods. Compounds 2 and 3 showed potent cytoprotective activity in tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity of HepG2 cells.

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