Proportion of Murine Cytotoxic T Cells is Increased by High Molecular-Weight Fucoidan Extracted from Okinawa mozuku (Cladosiphon okamuranus)

Jun Shimizu; Urara Wada-Funada; Hiroshi Mano; Yoshiharu Matahira; Mitsuaki Kawaguchi; Masahiro Wada

doi:10.1248/jhs.51.394

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Proportion of Murine Cytotoxic T Cells is Increased by High Molecular-Weight Fucoidan Extracted from Okinawa mozuku (Cladosiphon okamuranus)

Jun Shimizu, Urara Wada-Funada, Hiroshi Mano, Yoshiharu Matahira, Mitsuaki Kawaguchi, Masahiro Wada

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Keywords: fucoidan, cytotoxic T cell, lymphocyte, flow cytometry, mouse

JOURNAL FREE ACCESS

2005 Volume 51 Issue 3 Pages 394-397

DOI https://doi.org/10.1248/jhs.51.394

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Abstract

Male BALB/c mice were administered three fucoidans with different molecular weights prepared from Okinawa mozuku (Cladosiphon okamuranus). The proportion of CD8⁺ cells in the spleens of mice fed with high molecular-weight fucoidan significantly increased compared with those in mice fed a control diet. In addition, the CD4⁺/CD8⁺ ratio tended to decrease and the proportion of CD11b⁺ cells to increase. These results suggest that high molecular-weight fucoidan promotes an increase in the proportion of murine cytotoxic T cells.

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