Protective Effect of α-Lipoic Acid Against Arsenic Trioxide–Induced Acute Cardiac Toxicity in Rats

Masafumi Kumazaki; Hitoshi Ando; Akira Sasaki; Taka-aki Koshimizu; Kentarou Ushijima; Keiko Hosohata; Yasuo Oshima; Akio Fujimura

doi:10.1254/jphs.10280SC

Short Communications

Protective Effect of α-Lipoic Acid Against Arsenic Trioxide–Induced Acute Cardiac Toxicity in Rats

Masafumi Kumazaki, Hitoshi Ando, Akira Sasaki, Taka-aki Koshimizu, Kentarou Ushijima, Keiko Hosohata, Yasuo Oshima, Akio Fujimura

Author information

Masafumi Kumazaki
Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Japan
Hitoshi Ando
Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Japan
Akira Sasaki
Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Japan
Taka-aki Koshimizu
Division of Molecular Pharmacology, Department of Pharmacology, Jichi Medical University, Japan
Kentarou Ushijima
Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Japan
Keiko Hosohata
Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Japan
Yasuo Oshima
Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Japan
Akio Fujimura
Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Japan

Keywords: α-lipoic acid, arsenic trioxide, cardiac toxicity

JOURNAL FREE ACCESS

2011 Volume 115 Issue 2 Pages 244-248

DOI https://doi.org/10.1254/jphs.10280SC

View "Advance Publication" version (January 26, 2011).

Details

Abstract

The clinical use of arsenic trioxide (ATO) is often limited because of its adverse effects. We examined whether α-lipoic acid (LA) protects against the ATO-induced cardiac toxicity. In the chronic study, two of four rats suddenly died by the repeated dosing of ATO, whereas no deaths were observed in combination with LA. In the acute study, continuous ECG recording revealed that intravenous injection of ATO caused transient ST-T change, whereas pretreatment with LA abolished the ATO-induced ECG abnormality in all animals. These results suggest that LA protects against the ATO-induced acute cardiac toxicity and subsequent sudden death in rats.

Corresponding author

Register with J-STAGE for free!