Roles of Prostaglandin E2 in Cardiovascular Diseases Focus on the Potential Use of a Novel Selective EP4 Receptor Agonist

Jun-ichi Suzuki; Masahito Ogawa; Ryo Watanabe; Kiyoshi Takayama; Yasunobu Hirata; Ryozo Nagai; Mitsuaki Isobe

doi:10.1536/ihj.52.266

Review

Roles of Prostaglandin E2 in Cardiovascular Diseases

Focus on the Potential Use of a Novel Selective EP4 Receptor Agonist

Jun-ichi Suzuki, Masahito Ogawa, Ryo Watanabe, Kiyoshi Takayama, Yasunobu Hirata, Ryozo Nagai, Mitsuaki Isobe

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Keywords: Prostaglandin, Receptors, Chemokine, Macrophage, Heart

JOURNAL FREE ACCESS

2011 Volume 52 Issue 5 Pages 266-269

DOI https://doi.org/10.1536/ihj.52.266

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Abstract

Prostaglandin E2 (PGE₂) is produced in inflammatory responses and regulates a variety of immunological reactions through 4 different receptor subtypes; EP1, 2, 3 and 4. However, the precise role of each receptor in cardiovascular disease has not yet been elucidated. Enhanced expression of some EPs has been observed in clinical and experimental cardiovascular diseases. EP agonists have been developed to clarify the role of each receptor. Recently, we developed a novel selective agonist to examine the effects of EP4 on cardiac transplantation, myocardial ischemia, and myocarditis. Of note, a selective EP4 agonist attenuated inflammatory cytokines and chemokines via attenuation of macrophage activation in inflammatory heart diseases. In this review article, we discuss the effects of PGE₂ receptor agonists on the development of cardiovascular diseases.

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