Antioxidant and Anticancer Properties of Leaf and Fruit Extracts of the Wild Raspberry (Rubus idaeus L.)

Authors

  • Bojana VELJKOVIC State University of Novi Pazar, Department of Biomedical Sciences, Vuka Karadžića bb, 36300 Novi Pazar (RS)
  • Natasa DJORDJEVIC State University of Novi Pazar, Department of Biomedical Sciences, Vuka Karadžića bb, 36300 Novi Pazar (RS)
  • Zana DOLICANIN State University of Novi Pazar, Department of Biomedical Sciences, Vuka Karadžića bb, 36300 Novi Pazar (RS)
  • Braho LICINA State University of Novi Pazar, Department of Biomedical Sciences, Vuka Karadžića bb, 36300 Novi Pazar (RS)
  • Marina TOPUZOVIC University of Kragujevac, Faculty of Sciences, Institute for Biology and Ecology, Radoja Domanovića 12, 34000 Kragujevac (RS)
  • Milan STANKOVIC University of Kragujevac, Faculty of Sciences, Institute for Biology and Ecology, Radoja Domanovića 12, 34000 Kragujevac (RS)
  • Nenad ZLATIC University of Kragujevac, Faculty of Sciences, Institute for Biology and Ecology, Radoja Domanovića 12, 34000 Kragujevac (RS)
  • Zora DAJIC-STEVANOVIC University of Belgrade, Department of Agrobotany, Nemanjina 6, 11080 Zemun-Belgrade (RS)

DOI:

https://doi.org/10.15835/nbha47111274

Keywords:

biological activity; methanolic extracts; phytochemical analysis; secondary metabolites

Abstract

In this study the leaves and fruits of wild raspberry (Rubus idaeus L.) populations from the central Balkan region were examined to determine the level of secondary metabolites and related antioxidant activity, as well as biological activity, upon existing ethnobotanical evidence, primarily linked to gastrointestinal disorders. The values obtained for total phenols ranged from 59.68 to 96.83 mg GA g-1 and 24.29 to 38.71 mg GA g-1 in leaf and fruit extracts, respectively. The highest values of tannins and anthocyanins were determined for leaf extracts from a population of east Serbia at a level of 1.27 mg mL-1 and 9.00 mg mL-1. Antioxidant activity was evaluated by measuring the scavenging capacity of the extracts on DPPH. Higher antioxidant activity was detected in the leaf extracts than in the fruit extracts. Leaf and fruit extract were the most effective against Escherichia coli (ATCC 8739). Anticancer activity was studied on a human colorectal cancer cell line HCT-116. Leaf extracts exhibited anticancer activity with IC50/24 h 162.38 μg mL-1 and IC50/48 h 95.69 μg mL-1. Wild raspberry leaf and fruit extracts contain numerous secondary metabolites providing marked antioxidant, antimicrobial and anticancer activity.

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Published

2018-12-21

How to Cite

VELJKOVIC, B., DJORDJEVIC, N., DOLICANIN, Z., LICINA, B., TOPUZOVIC, M., STANKOVIC, M., ZLATIC, N., & DAJIC-STEVANOVIC, Z. (2018). Antioxidant and Anticancer Properties of Leaf and Fruit Extracts of the Wild Raspberry (Rubus idaeus L.). Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 47(2), 359–367. https://doi.org/10.15835/nbha47111274

Issue

Vol. 47 No. 2 (2019)

Section

Research Articles
CITATION
DOI: 10.15835/nbha47111274

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Copyright (c) 2018 Bojana VELJKOVIC, Natasa DJORDJEVIC, Zana DOLICANIN, Braho LICINA, Marina TOPUZOVIC, Milan STANKOVIC, Nenad ZLATIC, Zora DAJIC-STEVANOVIC

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