Fifty years ago, The Coleopterists Bulletin featured a series of articles on beetles and their interactions with the plant genus Toxicodendron P. Mill. section Toxicodendron (the poison ivies and poison oaks). Subsequent to the series, little progress has been made towards a better understanding of these relationships. The present work uses both original observations from field studies as well as a historical review of previous data to synthesize a more robust picture of coleopteran-Toxicodendron relationships. In addition to enumerating previously unrecognized associations, this paper demonstrates that numerous coleopteran taxa interact with Toxicodendron spp. in both mutualistic and parasitic capacities.