Abstract
Cell-penetrating peptides (CPPs) are promising tools for intracellular delivery. However, no consensus regarding their internalization mechanism has been reached within the scientific community. Although endocytosis seems to be the preferred internalization mechanism for most CPP-cargo complexes, examples of direct translocation have also been identified. In this review we go through the several ways of studying CPP-mediated cargo delivery in cells and the possible factors affecting the internalization pathways followed by these complexes. In addition, we analyze the CPP-mediated delivery of two relevant cargoes, namely quantum dots and nucleic acids, focusing on the internalization mechanism that they follow.
Keywords: Cell penetrating peptides, internalization mechanism, drug delivery, Quantum dot delivery and nucleic acid delivery
Current Pharmaceutical Design
Title:Intracellular Fate of Peptide-Mediated Delivered Cargoes
Volume: 19 Issue: 16
Author(s): Irene Martin, Meritxell Teixido and Ernest Giralt
Affiliation:
Keywords: Cell penetrating peptides, internalization mechanism, drug delivery, Quantum dot delivery and nucleic acid delivery
Abstract: Cell-penetrating peptides (CPPs) are promising tools for intracellular delivery. However, no consensus regarding their internalization mechanism has been reached within the scientific community. Although endocytosis seems to be the preferred internalization mechanism for most CPP-cargo complexes, examples of direct translocation have also been identified. In this review we go through the several ways of studying CPP-mediated cargo delivery in cells and the possible factors affecting the internalization pathways followed by these complexes. In addition, we analyze the CPP-mediated delivery of two relevant cargoes, namely quantum dots and nucleic acids, focusing on the internalization mechanism that they follow.
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Cite this article as:
Martin Irene, Teixido Meritxell and Giralt Ernest, Intracellular Fate of Peptide-Mediated Delivered Cargoes, Current Pharmaceutical Design 2013; 19 (16) . https://dx.doi.org/10.2174/1381612811319160007
DOI https://dx.doi.org/10.2174/1381612811319160007 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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