Abstract
Mucositis is a common side effect of chemotherapy which remains poorly understood. Despite advances in the understanding of oral and small intestinal mucositis over recent years, large intestinal mucositis, including diarrhoea, has not been well defined and the underlying mechanisms of the condition are yet to be established. The majority of the literature available concerning large intestinal mucositis is based on clinical observations, with very little basic research existing. However, from the little research conducted, it is likely that the intestinal microflora play a role in the development of chemotherapy-induced mucositis. This review will explore the potentially important relationship between intestinal microflora and the subsequent development of chemotherapy-induced mucositis.
Current Drug Metabolism
Title: Chemotherapy-Induced Modifications to Gastrointestinal Microflora: Evidence and Implications of Change
Volume: 10 Issue: 1
Author(s): Andrea M. Stringer, Rachel J. Gibson, Joanne M. Bowen and Dorothy M.K. Keefe
Affiliation:
Abstract: Mucositis is a common side effect of chemotherapy which remains poorly understood. Despite advances in the understanding of oral and small intestinal mucositis over recent years, large intestinal mucositis, including diarrhoea, has not been well defined and the underlying mechanisms of the condition are yet to be established. The majority of the literature available concerning large intestinal mucositis is based on clinical observations, with very little basic research existing. However, from the little research conducted, it is likely that the intestinal microflora play a role in the development of chemotherapy-induced mucositis. This review will explore the potentially important relationship between intestinal microflora and the subsequent development of chemotherapy-induced mucositis.
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Cite this article as:
Stringer M. Andrea, Gibson J. Rachel, Bowen M. Joanne and Keefe M.K. Dorothy, Chemotherapy-Induced Modifications to Gastrointestinal Microflora: Evidence and Implications of Change, Current Drug Metabolism 2009; 10 (1) . https://dx.doi.org/10.2174/138920009787048419
DOI https://dx.doi.org/10.2174/138920009787048419 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
Call for Papers in Thematic Issues
Interaction between drugs and endocrine diseases
The introduction of highly active antiretroviral therapy accelerated studies and our understanding on the interaction between pharmacological therapies and endocrine diseases. Drugs can precipitate endocrine via different mechanisms, including direct alteration of hormone production and secretion, dysregulation of hormonal axis, effects on hormonal transport, receptor-binding, and cellular signalling. Common drug-induced ...read more
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