Abstract
The emergence of bacteria resistance to most of the currently available antibiotics has become a critical therapeutic problem. The bacteria causing both hospital and community-acquired infections are most often multidrug resistant. In view of the alarming level of antibiotic resistance between bacterial species and difficulties with treatment, alternative or supportive antibacterial cure has to be developed. The presented review focuses on the major characteristics of bacteriophages and phage-encoded proteins affecting their usefulness as antimicrobial agents. We discuss several issues such as mode of action, pharmacodynamics, pharmacokinetics, resistance and manufacturing aspects of bacteriophages and phage-encoded proteins application.
Keywords: antibiotics, bacterial multidrug resistance, bacteriophage therapy, phage-encoded proteins application, Bacteriophages, ANTIMICROBIAL DRUG RESISTANCE, Bacterial Anti-Phage Resistance, PHAGE-ENCODED PROTEINS, EPS- Degrading Phage Enzymes, Bacterial Protein Synthesis
Current Protein & Peptide Science
Title:Learning from Bacteriophages - Advantages and Limitations of Phage and Phage-Encoded Protein Applications
Volume: 13 Issue: 8
Author(s): Zuzanna Drulis-Kawa, Grazyna Majkowska-Skrobek, Barbara Maciejewska, Anne-Sophie Delattre and Rob Lavigne
Affiliation:
Keywords: antibiotics, bacterial multidrug resistance, bacteriophage therapy, phage-encoded proteins application, Bacteriophages, ANTIMICROBIAL DRUG RESISTANCE, Bacterial Anti-Phage Resistance, PHAGE-ENCODED PROTEINS, EPS- Degrading Phage Enzymes, Bacterial Protein Synthesis
Abstract: The emergence of bacteria resistance to most of the currently available antibiotics has become a critical therapeutic problem. The bacteria causing both hospital and community-acquired infections are most often multidrug resistant. In view of the alarming level of antibiotic resistance between bacterial species and difficulties with treatment, alternative or supportive antibacterial cure has to be developed. The presented review focuses on the major characteristics of bacteriophages and phage-encoded proteins affecting their usefulness as antimicrobial agents. We discuss several issues such as mode of action, pharmacodynamics, pharmacokinetics, resistance and manufacturing aspects of bacteriophages and phage-encoded proteins application.
Export Options
About this article
Cite this article as:
Drulis-Kawa Zuzanna, Majkowska-Skrobek Grazyna, Maciejewska Barbara, Delattre Anne-Sophie and Lavigne Rob, Learning from Bacteriophages - Advantages and Limitations of Phage and Phage-Encoded Protein Applications, Current Protein & Peptide Science 2012; 13 (8) . https://dx.doi.org/10.2174/138920312804871193
DOI https://dx.doi.org/10.2174/138920312804871193 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
Call for Papers in Thematic Issues
Advancements in Proteomic and Peptidomic Approaches in Cancer Immunotherapy: Unveiling the Immune Microenvironment
The scope of this thematic issue centers on the integration of proteomic and peptidomic technologies into the field of cancer immunotherapy, with a particular emphasis on exploring the tumor immune microenvironment. This issue aims to gather contributions that illustrate the application of these advanced methodologies in unveiling the complex interplay ...read more
Nutrition and Metabolism in Musculoskeletal Diseases
The musculoskeletal system consists mainly of cartilage, bone, muscles, tendons, connective tissue and ligaments. Balanced metabolism is of vital importance for the homeostasis of the musculoskeletal system. A series of musculoskeletal diseases (for example, sarcopenia, osteoporosis) are resulted from the dysregulated metabolism of the musculoskeletal system. Furthermore, metabolic diseases (such ...read more
Protein Folding, Aggregation and Liquid-Liquid Phase Separation
Protein folding, misfolding and aggregation remain one of the main problems of interdisciplinary science not only because many questions are still open, but also because they are important from the point of view of practical application. Protein aggregation and formation of fibrillar structures, for example, is a hallmark of a ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Taming the Storm in the Heart: Exploring Different Therapeutic Choices Against Myocardial Inflammation in COVID-19
Recent Advances in Anti-Infective Drug Discovery History, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19)
Coronaviruses Investigation of 2-Fluoro Benzoic Acid Derivatives as Influenza A Viral Sialidase Selective Inhibitors
Anti-Infective Agents in Medicinal Chemistry A Sustainable Approach to Bis-Indole Synthesis Using Propylene Carbonate as an Eco-Friendly Solvent
Current Organic Synthesis Inhibition of glycine transporter 1: The yellow brick road to new schizophrenia therapy?
Current Pharmaceutical Design Meet Our Editorial Board Member
Current Neuropharmacology Non-Covalent Cathepsin K Inhibitors for the Treatment of Osteoporosis
Current Topics in Medicinal Chemistry Styrylbenzimidazoles. Synthesis and Biological Activity - Part 3
Medicinal Chemistry New Prospects for Glycopeptide Based Analgesia: Glycoside-Induced Penetration of the Blood-Brain Barrier
Current Drug Delivery Chemistry and Anticancer Activity of Hybrid Molecules and Derivatives based on 5-Fluorouracil
Current Medicinal Chemistry A Review on Polymeric Invasive and Non-Invasive Nanocarriers Assisted Transdermal Drug Delivery for Improved Penetration and Bioavailability
Drug Delivery Letters The Utilization of the Monte Carlo Technique for Rational Drug Discovery
Combinatorial Chemistry & High Throughput Screening Interplay between SARS-CoV-2 and Cancer: Plausible Risk Factors, Cellular Immune Responses, Cancer Directed Therapy- Current Challenges
Infectious Disorders - Drug Targets “COVID-19 is Here to Stay”
Current Respiratory Medicine Reviews Diversity in Antibacterial Activity of Thiosemicarbazides Derived from 3-Chlorobenzhydrazide
Letters in Drug Design & Discovery Benzophenone Esters and Sulfonates: Synthesis and their Potential as Antiinflammatory Agents
Medicinal Chemistry Structural Investigation of Vinca Domain Tubulin Binders by Pharmacophore, Atom based QSAR, Docking and Molecular Dynamics Simulations
Combinatorial Chemistry & High Throughput Screening Anticancer Drug-Induced Immunomodulation and Cancer Therapeutics
Current Cancer Therapy Reviews Thwarting Coronavirus Infections by Tapping Host Targets: The ‘Greek Gift Sacrifice’ to Curb the Menace of Drug Resistances
Current Molecular Pharmacology Differential Response to Three Antidepressants in Patients with Major Depressive Episode Who Suffered Covid-19-Related Trauma
Current Neuropharmacology