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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Cytotoxicity and Toxicity to Animals and Humans of Ribosome-Inactivating Proteins

Author(s): Maria Giulia Battelli

Volume 4, Issue 5, 2004

Page: [513 - 521] Pages: 9

DOI: 10.2174/1389557043403819

Price: $65

Abstract

The toxicity to cells and animals of type 1 and toxic and non-toxic type 2 Ribosome-Inactivating Proteins (RIP) is discussed in correlation with their catalytic activity, resulting in ribosome inactivation and apoptosis. The symptoms and histopathological lesions induced by RIP to animals and humans is also reviewed.

Keywords: cytotoxicity, toxicity to animals, toxicity to humans, type 1 ribosome-inactivating proteins, toxic type 2 ribosome-inactivating proteins, non-toxic type 2 ribosome-inactivating proteins


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