Abstract
Recent evidence suggests that antiglucocorticoids, like conventional antidepressants, may recover depressive symptoms by boosting hippocampal neurogenesis. Here, we explore several possible antiglucocorticoid-based antidepressive therapeutic strategies. Firstly, we review specific glucocorticoid receptor/antagonist interactions. Secondly, we discuss a potential new therapeutic target, doublecortin-like kinase, which regulates glucocorticoid signaling in neuronal progenitor cells.
Keywords: Stress, glucocorticoid receptor, dentate gyrus, hippocampus, neurogenesis, antidepressants, depression, doublecortin- like kinase, anti-glucocorticoids
Mini-Reviews in Medicinal Chemistry
Title: Antiglucocorticoids, Neurogenesis and Depression
Volume: 9 Issue: 2
Author(s): Carlos P. Fitzsimons, Lenneke W.A. van Hooijdonk, John A. Morrow, Bernard W.M.M. Peeters, Niall Hamilton, Mark Craighead and Erno Vreugdenhil
Affiliation:
Keywords: Stress, glucocorticoid receptor, dentate gyrus, hippocampus, neurogenesis, antidepressants, depression, doublecortin- like kinase, anti-glucocorticoids
Abstract: Recent evidence suggests that antiglucocorticoids, like conventional antidepressants, may recover depressive symptoms by boosting hippocampal neurogenesis. Here, we explore several possible antiglucocorticoid-based antidepressive therapeutic strategies. Firstly, we review specific glucocorticoid receptor/antagonist interactions. Secondly, we discuss a potential new therapeutic target, doublecortin-like kinase, which regulates glucocorticoid signaling in neuronal progenitor cells.
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Cite this article as:
Fitzsimons P. Carlos, van Hooijdonk W.A. Lenneke, Morrow A. John, Peeters W.M.M. Bernard, Hamilton Niall, Craighead Mark and Vreugdenhil Erno, Antiglucocorticoids, Neurogenesis and Depression, Mini-Reviews in Medicinal Chemistry 2009; 9 (2) . https://dx.doi.org/10.2174/138955709787316001
DOI https://dx.doi.org/10.2174/138955709787316001 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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