Abstract
Anthocyanins are the chemical components that give the intense color to many fruits and vegetables, such as blueberries, red cabbages and purple sweet potatoes. Epidemiological investigations have indicated that the moderate consumption of anthocyanin products such as red wine or bilberry extract is associated with a lower risk of cardiovascular disease and improvement of visual functions. Recently, there is increasing interesting in the pharmaceutical function of anthocyanins. This review summarizes current knowledge on the various molecular evidences of cancer chemoprevention by anthocyanins. These mechanisms can be subdivided into the following aspects: 1) the antioxidation, 2) the molecular mechanisms involved in anticarcinogenesis, 3) the molecular mechanisms involved in the apoptosis induction of tumor cells. Finally, the bioavailability and structure-activity relationship of anthocyanins are also summarized.
Keywords: Cancer Chemoprevention, apoptosis, tumor cells, anticarcinogenesis, antioxidation
Current Molecular Medicine
Title: Potential Mechanisms of Cancer Chemoprevention by Anthocyanins
Volume: 3 Issue: 2
Author(s): De-Xing Hou
Affiliation:
Keywords: Cancer Chemoprevention, apoptosis, tumor cells, anticarcinogenesis, antioxidation
Abstract: Anthocyanins are the chemical components that give the intense color to many fruits and vegetables, such as blueberries, red cabbages and purple sweet potatoes. Epidemiological investigations have indicated that the moderate consumption of anthocyanin products such as red wine or bilberry extract is associated with a lower risk of cardiovascular disease and improvement of visual functions. Recently, there is increasing interesting in the pharmaceutical function of anthocyanins. This review summarizes current knowledge on the various molecular evidences of cancer chemoprevention by anthocyanins. These mechanisms can be subdivided into the following aspects: 1) the antioxidation, 2) the molecular mechanisms involved in anticarcinogenesis, 3) the molecular mechanisms involved in the apoptosis induction of tumor cells. Finally, the bioavailability and structure-activity relationship of anthocyanins are also summarized.
Export Options
About this article
Cite this article as:
Hou De-Xing, Potential Mechanisms of Cancer Chemoprevention by Anthocyanins, Current Molecular Medicine 2003; 3 (2) . https://dx.doi.org/10.2174/1566524033361555
DOI https://dx.doi.org/10.2174/1566524033361555 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Pharmacotherapeutic Potential of Garlic in Age-Related Neurological Disorders
CNS & Neurological Disorders - Drug Targets Advances in Sickle Cell Disease Treatment: from Drug Discovery Until the Patient Monitoring
Cardiovascular & Hematological Agents in Medicinal Chemistry Omega-3 Polyunsaturated Fatty Acids and Cancer
Anti-Cancer Agents in Medicinal Chemistry Cardiovascular Involvement in Pediatric Systemic Autoimmune Diseases: The Emerging Role of Noninvasive Cardiovascular Imaging
Inflammation & Allergy - Drug Targets (Discontinued) The Role and Impact of SNPs in Pharmacogenomics and Personalized Medicine
Current Drug Metabolism A Systematic Review of Subacute Thyroiditis Related to COVID-19
New Emirates Medical Journal Sudden Infant Death Syndrome: A Review of the Literature
Current Pediatric Reviews Quantum Pharmacology for Infectious Diseases: A Molecular Connectivity Approach
Current Computer-Aided Drug Design The Role of Antihistamine Drugs in Allergic Disorders
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents A Comprehensive Review of the Genus Pyrola Herbs in Traditional Uses, Phytochemistry and Pharmacological Activities
Current Topics in Medicinal Chemistry Physical Activity: Do Patients Infected with HIV Practice? How Much? A Systematic Review
Current HIV Research Effects of Maternal Obesity on Maternal and Fetal Health
Current Women`s Health Reviews Differential Effects of Efavirenz and Lopinavir/Ritonavir on Human Adipocyte Differentiation, Gene Expression and Release of Adipokines and Pro-Inflammatory Cytokines.
Current HIV Research The Effects of Lipid-Regulating Therapy on Haemostatic Parameters
Current Pharmaceutical Design Modern Developments in the Spray-Drying Industries
Recent Patents on Materials Science Fetal Programming of the Human Brain: Is there a Link with Insurgence of Neurodegenerative Disorders in Adulthood?
Current Medicinal Chemistry Low Lymphocyte Count and Cardiovascular Diseases
Current Medicinal Chemistry Strategies and Techniques for Multi-Component Drug Design from Medicinal Herbs and Traditional Chinese Medicine
Current Topics in Medicinal Chemistry Progress in the Oral Treatment of Type 2 Diabetes: Update on DPP-IV Inhibitors
Current Diabetes Reviews Quantitative Analysis of Metformin with Special Emphasis on Sensors: A Review
Current Analytical Chemistry