Abstract
Conjugates containing nigrin b (two-chain RIP) linked to a new lectin (SELld) from Sambucus ebulus L. have been designed. They retain the anti-ribosomal inhibitory activity of nigrin b but, in contrast to nigrin b, they exerted strong cytotoxicity on COLO 320 and HeLa cells, which ran in parallel with DNA fragmentation.
Keywords: nigrin b, selld, ribosome-inactivating proteins, colo 320 cells, cancer therapy, apoptosis
Letters in Drug Design & Discovery
Title: Design and Cytotoxicity Analysis of a Conjugate Containing the New DGalactose- Binding Lectin SELld and the Non-Toxic Type 2 Ribosome- Inactivating Protein Nigrin b
Volume: 1 Issue: 4
Author(s): Jorge Benitez, M. Angeles Rojo, Raquel Munoz, J. Miguel Ferreras, Pilar Jimenez and Tomas Girbes
Affiliation:
Keywords: nigrin b, selld, ribosome-inactivating proteins, colo 320 cells, cancer therapy, apoptosis
Abstract: Conjugates containing nigrin b (two-chain RIP) linked to a new lectin (SELld) from Sambucus ebulus L. have been designed. They retain the anti-ribosomal inhibitory activity of nigrin b but, in contrast to nigrin b, they exerted strong cytotoxicity on COLO 320 and HeLa cells, which ran in parallel with DNA fragmentation.
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Cite this article as:
Benitez Jorge, Rojo Angeles M., Munoz Raquel, Ferreras Miguel J., Jimenez Pilar and Girbes Tomas, Design and Cytotoxicity Analysis of a Conjugate Containing the New DGalactose- Binding Lectin SELld and the Non-Toxic Type 2 Ribosome- Inactivating Protein Nigrin b, Letters in Drug Design & Discovery 2004; 1 (4) . https://dx.doi.org/10.2174/1570180043398687
DOI https://dx.doi.org/10.2174/1570180043398687 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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