Novel Thiazolidinone Derivatives with an Uncommon Mechanism of Inhibition Towards HIV-1 Reverse Transcriptase

Title: Novel Thiazolidinone Derivatives with an Uncommon Mechanism of Inhibition Towards HIV-1 Reverse Transcriptase

Volume: 7 Issue: 4

Author(s): Eleni Pitta, Emmanuele Crespan, Athina Geronikaki, Giovanni Maga and Alberta Samuele

Affiliation:

Keywords: HIV-1 RT, HAART, NNRTIs, AIDS, Antiretroviral therapy, Enzyme kinetics

Abstract: Here, we show that novel 2-aryl-3-(4-adamantyl-thiazol-21,3-thiazolidin-4-one derivatives have a mixed- or fully competitive mechanism of inhibition towards HIV-1 Reverse Transcriptase with respect to the substrates of the reaction. Thus, they are interesting starting points for the development of novel NNRTIs with an uncommon mechanism of action.

Cite this article as:

Pitta Eleni, Crespan Emmanuele, Geronikaki Athina, Maga Giovanni and Samuele Alberta, Novel Thiazolidinone Derivatives with an Uncommon Mechanism of Inhibition Towards HIV-1 Reverse Transcriptase, Letters in Drug Design & Discovery 2010; 7 (4) . https://dx.doi.org/10.2174/157018010790945869