Abstract
Many important biological processes including fertilization, tissue formation, cell adhesion, antigen/antibody interactions, cancer metastasis or pathogen infection involve polyvalent interactions between oligomeric proteins and carbohydrate-based ligands. The synthesis of multitopic, molecularly-defined structures that display both clustered sugars and immobilization or bioactive agents represents an attractive approach for the discovery of new diagnostics and therapeutics. This mini-review updates the current developments in this field by focusing on the recent interests on cyclopeptide-based glycoclusters.
Keywords: Cyclopeptide, glycocluster, multivalency, carbohydrate, solid-phase synthesis, oxime ligation
Mini-Reviews in Organic Chemistry
Title: Recent Advances on Cyclopeptide-Based Glycoclusters
Volume: 5 Issue: 4
Author(s): Olivier Renaudet
Affiliation:
Keywords: Cyclopeptide, glycocluster, multivalency, carbohydrate, solid-phase synthesis, oxime ligation
Abstract: Many important biological processes including fertilization, tissue formation, cell adhesion, antigen/antibody interactions, cancer metastasis or pathogen infection involve polyvalent interactions between oligomeric proteins and carbohydrate-based ligands. The synthesis of multitopic, molecularly-defined structures that display both clustered sugars and immobilization or bioactive agents represents an attractive approach for the discovery of new diagnostics and therapeutics. This mini-review updates the current developments in this field by focusing on the recent interests on cyclopeptide-based glycoclusters.
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Renaudet Olivier, Recent Advances on Cyclopeptide-Based Glycoclusters, Mini-Reviews in Organic Chemistry 2008; 5 (4) . https://dx.doi.org/10.2174/157019308786242142
DOI https://dx.doi.org/10.2174/157019308786242142 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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