Abstract
Molecular genetic markers represent one of the most powerful tools for the analysis of genomes and enable the association of heritable traits with underlying genomic variation. Molecular marker technology has developed rapidly over the last decade and two forms of sequence based marker, Simple Sequence Repeats (SSRs), also known as microsatellites, and Single Nucleotide Polymorphisms (SNPs) now predominate applications in modern genetic analysis. The reducing cost of DNA sequencing has led to the availability of large sequence data sets derived from whole genome sequencing and large scale Expressed Sequence Tag (EST) discovery that enable the mining of SSRs and SNPs, which may then be applied to diversity analysis, genetic trait mapping, association studies, and marker assisted selection. These markers are inexpensive, require minimal labour to produce and can frequently be associated with annotated genes. Here we review automated methods for the discovery of SSRs and SNPs and provide an overview of the diverse applications of these markers.
Keywords: Simple sequence repeats (SSRs), single nucleotide polymorphisms (SNPs), molecular markers, expressed sequence tags (ESTs), genome sequencing
Current Bioinformatics
Title: Molecular Genetic Markers: Discovery, Applications, Data Storage and Visualisation
Volume: 4 Issue: 1
Author(s): Chris Duran, Nikki Appleby, David Edwards and Jacqueline Batley
Affiliation:
Keywords: Simple sequence repeats (SSRs), single nucleotide polymorphisms (SNPs), molecular markers, expressed sequence tags (ESTs), genome sequencing
Abstract: Molecular genetic markers represent one of the most powerful tools for the analysis of genomes and enable the association of heritable traits with underlying genomic variation. Molecular marker technology has developed rapidly over the last decade and two forms of sequence based marker, Simple Sequence Repeats (SSRs), also known as microsatellites, and Single Nucleotide Polymorphisms (SNPs) now predominate applications in modern genetic analysis. The reducing cost of DNA sequencing has led to the availability of large sequence data sets derived from whole genome sequencing and large scale Expressed Sequence Tag (EST) discovery that enable the mining of SSRs and SNPs, which may then be applied to diversity analysis, genetic trait mapping, association studies, and marker assisted selection. These markers are inexpensive, require minimal labour to produce and can frequently be associated with annotated genes. Here we review automated methods for the discovery of SSRs and SNPs and provide an overview of the diverse applications of these markers.
Export Options
About this article
Cite this article as:
Duran Chris, Appleby Nikki, Edwards David and Batley Jacqueline, Molecular Genetic Markers: Discovery, Applications, Data Storage and Visualisation, Current Bioinformatics 2009; 4 (1) . https://dx.doi.org/10.2174/157489309787158198
DOI https://dx.doi.org/10.2174/157489309787158198 |
Print ISSN 1574-8936 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-392X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Translational Medicine in Neurological Disorders: A Genomic Perspective
Current Genomics Can the Sigma-1 Receptor Agonist Fluvoxamine Prevent Schizophrenia?
CNS & Neurological Disorders - Drug Targets Potential of Antibiotics for the Treatment and Management of Parkinson's Disease: An Overview
Current Drug Research Reviews The µ Opioid Receptor and Ligands Acting at the µ Opioid Receptor, as Therapeutics and Potential Therapeutics
Current Pharmaceutical Design Curcuminoids in Neurodegenerative Diseases
Recent Patents on CNS Drug Discovery (Discontinued) Glutamate and Schizophrenia: Pathophysiology and Therapeutics
Current Medicinal Chemistry - Central Nervous System Agents ADAM Proteases: Protective Role in Alzheimers and Prion Diseases ?
Current Alzheimer Research Inhibition of glycine transporter 1: The yellow brick road to new schizophrenia therapy?
Current Pharmaceutical Design Target Recognition in SAR Image by Joint Classification of Target Region and Shadow
Recent Advances in Electrical & Electronic Engineering Ziconotide Monotherapy: A Systematic Review of Randomised Controlled Trials
Current Neuropharmacology Nose to Brain Delivery: New Trends in Amphiphile-Based “Soft” Nanocarriers
Current Pharmaceutical Design Probing Gallic Acid for Its Broad Spectrum Applications
Mini-Reviews in Medicinal Chemistry Microdose Lithium NP03 Diminishes Pre-Plaque Oxidative Damage and Neuroinflammation in a Rat Model of Alzheimer’s-like Amyloidosis
Current Alzheimer Research Role of Pituitary Adenylate Cyclase-Activating Polypeptide in Nociception and Migraine
CNS & Neurological Disorders - Drug Targets Failure Mode and Effects Analysis to Reduce Risks of Errors in the Good Manufacturing Practice Production of Engineered Cartilage for Autologous Chondrocyte Implantation
Current Pharmaceutical Analysis Reactive Oxygen Species: Physiological Roles in the Regulation of Vascular Cells
Current Molecular Medicine Meet the Editorial Board:
Central Nervous System Agents in Medicinal Chemistry Animal Models in Neurology: Drawbacks and Opportunities
Current Pharmaceutical Design Osteoimmunology and Beyond
Current Medicinal Chemistry Pharmacogenetic Insights into Depression and Antidepressant Response: Does Sex Matter?
Current Pharmaceutical Design