Journal of the Serbian Chemical Society 2006 Volume 71, Issue 12, Pages: 1275-1280
https://doi.org/10.2298/JSC0612275K
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Pyrrolizidine alkaloids from Bulgarian species of the genus Senecio
Kostova Nadezhda (Institute of organic chemistry with Centre of phytochemistry, Bulgarian Academy of sciences, Sofia)
Christov Veselin (Institute of organic chemistry with Centre of phytochemistry, Bulgarian Academy of sciences, Sofia)
Cholakova Maia (Institute of experimental morphology and anthropology, Bulgarian Academy of sciences, Sofia)
Nikolova Elena (Institute of experimental morphology and anthropology, Bulgarian Academy of sciences, Sofia)
Evstatieva Liuba (Institute of botany, Bulgarian Academy of sciences, Sofia,)
Nine Bulgarian species from the genus Senecio were studied phytochemically and/or by GC-MS analysis. Senecivernine-N-oxide was isolated and identified by spectral data for the first time. Different types of pyrrolizidine alkaloids were tested for cytotoxicity on murine lymphocytes. At a concentration of 100 μg/ml, the alkaloid retroisosenine showed immunosuppressive effect. .
Keywords: Senecio, senecivernine-N-oxide, cytotoxicity, lymphocyte