This study investigated associations between individual and work-related factors and perceived mastery of work among offshore shift workers. 2,406 employees of a Norwegian petroleum company were invited to participate. A web-based survey was used and 1336 completed questionnaires were returned (56%). Mastery of work was assessed using QPS Nordic Mastery Scale and the results were compared with a sample from the QPS Nordic study. Individual factors adjusted for were age, gender, marital status and personality. The following work-related factors were included: demands, control, support, night work and shift work home interference. Female offshore shift workers reported higher levels of perceived mastery of work compared with women in the comparison sample. The following variables were independently associated with perceived mastery of work: female gender (β=0.10, p=0.008), decisional demands (β=0.13, p<0.001), control (β=0.05, p=0.009), social support (β=0.07, p<0.001), shift-work locus of control (β=0.04, p=0.005) and neuroticism (β=–0.29, p<0.001). Post hoc analyses showed no sex differences in perceived mastery in two separate work positions on the platforms. Work-related variables and personality explained 55% and 45% respectively of the total variance (R²=0.22) explained by the final model. Female petroleum offshore workers reported somewhat higher levels of mastery of work than their male colleagues, however, this may be due to different work positions. Work-related factors accounted for about half of the explained variance and decisional demands, control and support remained statistically significant after controlling for personality.