Simulation of Gold Nanoparticles Aggravating MEMS Cantilever Optical Static Detection Biochip

Yue Tao Ge; Xiao Tong Yin

doi:10.4028/www.scientific.net/AMR.694-697.966

Paper Titles

Cooperative Positioning Based on Hybrid Information
p.940

Cure-Induced Strain Development in an RTM Epoxy Resin as Monitored by Fiber Bragg Grating Sensors
p.947

Fast and High Precision Thermoelectric Potential – Temperature Conversion Method for Aerodynamic Heating Control Systems
p.955

Forest Fire Detection System Based on Zigbee Wireless Sensor Network
p.961

Simulation of Gold Nanoparticles Aggravating MEMS Cantilever Optical Static Detection Biochip
p.966

System Design of a Fifth-Order Close-Loop ΣΔ Accelerometer
p.971

The Research of Straight Pipe Viscometer
p.976

A Torque Measuring Method for Robot Joints with Harmonic Drives
p.981

An Overview of Optical Voltage Sensor Based on Pockels Effect
p.987

HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 694-697Simulation of Gold Nanoparticles Aggravating MEMS...

Simulation of Gold Nanoparticles Aggravating MEMS Cantilever Optical Static Detection Biochip

Abstract:

A kind of gene detection biochip model based on biological micro electro mechanical systems (BioMEMS) technology and micro optical electro mechanical systems (MOEMS) technology is designed and simulated. In order to detect whether there are nucleic acid components in the testing samples, the biochip in this study issues horizontal light by laser, then receives and reads the deformation signals of MEMS cantilever by optical detector. The MEMS optical reflecting system can amplify MEMS cantilever deformation signal 22 times by micro reflectors which are set on the side wall of the cantilever free end. In order to improve optical detection sensitivity, gold nanoparticles (GNPs) which are combined with hybridization information is taken to aggravate MEMS cantilever, and employ Au - S chemical bond of GNPs and dithiol HS(CH₂)₆SH to combine and fix DNA probe, and then employ target DNA which is marked with biotin to combine GNPs by Biotin - Streptavidin combining. The simulation results show that this biochip can detect biological samples fast, high throughput, low cost, high sensitivity and reliably.

You might also be interested in these eBooks

View Preview

Info:

Periodical:

Advanced Materials Research (Volumes 694-697)

Pages:

966-970

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.694-697.966

Citation:

Cite this paper

Online since:

May 2013

Authors:

Yue Tao Ge, Xiao Tong Yin

Keywords:

Biochip, Gold Nanoparticles (GNP), MEMS, Simulation

Export:

RIS, BibTeX

Price:

Permissions:

Request Permissions

References

[1] Maria Gaczynska, and Pawel A. Osmulski, AFM of biological complexes: What can we learn? Current Opinion in Colloid & Interface Science, vol. 13, no. 5, 2008. pp.351-367.

DOI: 10.1016/j.cocis.2008.01.004

Google Scholar

[2] Zhongliang Deng, Yuetao Ge, Weiguo Guan, Naibo Zhang, Qike Cao. Nanogold aggravating MEMS cantilever capacitance detection biochip [J], Advanced Materials Research. 2011. (159). 429-433.

DOI: 10.4028/www.scientific.net/amr.159.429

Google Scholar

[3] Algre E., Legrand B., Faucher M., Walter B. and Buchaillot L., Surface microscopy with laserless MEMS based AFM probes, Micro Electro Mechanical Systems (MEMS), 2010 IEEE 23rd International Conference on. Wanchai Hong Kong, 2010. pp.292-295.

DOI: 10.1109/memsys.2010.5442509

Google Scholar

[4] Zhongliang Deng, Yuetao Ge, Qike Cao, Ke Han. The detection of a transgenic soybean biochip using gold label silver stain technology [J], Bioorganic & Medicinal Chemistry Letters. 2011. 21(22). 6905-6908.

DOI: 10.1016/j.bmcl.2011.07.037

Google Scholar

[5] J. Fritz, M. K. Baller, H. p. Lang, H. Rothuizen, P. Vettiger, E. Meyer, H. –J. Güntherodt, Ch. Gerber, J. K. Gimzewski, Translating Biomolecular Recognition into Nanomechanics, Science 288(5464), 2000. pp.316-318.

DOI: 10.1126/science.288.5464.316

Google Scholar

[6] Zhongliang Deng, Yuetao Ge, Weiguo Guan, Qike Cao. MEMS-based micro chamber PCR chip thermal analysis and structural improvement [A], 2010 IEEE International Conference on Computer, Mechatronics, Control and Electronic Engineering (CMCE 2010) [C]. Changchun China. 24-26 Aug. 2010. 130-133.

DOI: 10.1109/cmce.2010.5609894

Google Scholar

[7] Carrara S., Cavallini A., Leblebici Y., De Micheli, G.; Bhalla, V.; Valle, F.; Samori B., Benini L., Ricco B., Vikholm-Lundin I., Munter T., New probe immobilizations by lipoate-diethalonamines or ethylene-glycol molecules for capacitance DNA chip, Advances in sensors and Interfaces, 2009. IWASI 2009. 3rd International Workshop. Trani Italy, 2009. pp.9-14.

DOI: 10.1109/iwasi.2009.5184759

Google Scholar

[8] Zhongliang Deng, Yuetao Ge, Weiguo Guan, Naibo Zhang, Qike Cao. Nanogold aggravating MEMS cantilever piezoelectric optical detection biochip [J], Applied Mechanics and Materials. 2011. (39). 198-202.

DOI: 10.4028/www.scientific.net/amm.39.198

Google Scholar

[9] Tokachichu D.R., Bhushan B., Bioadhesion of polymers for BioMEMS, IEEE Trans. Nanotech. vol. 5, no. 3, 2006. pp.228-231.

DOI: 10.1109/tnano.2006.874047

Google Scholar