Osteoconductivity of Porous Titanium Having Young’s Modulus Similar to Bone and Surface Modification by OCP

Yuko Suzuki; Naoyuki Nomura; Shuji Hanada; Shinji Kamakura; Takahisa Anada; Takeshi Fuji; Yoshitomo Honda; Taisuke Masuda; Keiichi Sasaki; Shoichi Kokubun; Osamu Suzuki

doi:10.4028/www.scientific.net/KEM.330-332.951

Paper Titles

In Vitro Evaluation of Porous Biphasic Scaffolds
p.935

Investigation on the Biomimetic Scaffold for Bone Tissue Engineering Based on Bioglass-Collagen-Hyaluronic Acid-Phosphatidylserine
p.939

Biomimetic Bone Graft with Higher Bioactivity
p.943

Study on Hydroxylapatite Fibroin Porous Composite
p.947

Osteoconductivity of Porous Titanium Having Young’s Modulus Similar to Bone and Surface Modification by OCP
p.951

Apatite Formation on Porous HA/TCP in Animals’ Serums In Vitro
p.955

The New Art of Bone Graft Substitute Design
p.959

Comparison among Four Kinds of Bone Tissue Engineering Scaffold
p.963

Novel Micro-CT Based 3-Dimentional Structural Analyses of Porous Biomaterials
p.967

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Osteoconductivity of Porous Titanium Having Young’s Modulus Similar to Bone and Surface Modification by OCP

Abstract:

The present study was designed to investigate whether porous titanium (Ti) having Young’s modulus similar to bone has osteoconductive characteristics in rat critical-sized calvarial bone defect. The effect of coating by octacalcium phosphate (OCP) was also examined. OCP is known as a precursor of initial mineral crystals of biological apatite in bones and teeth. Ti powder was prepared by plasma rotating electrode process in an Ar atmosphere. Then, porous Ti disks, 8 mm in diameter with 1 mm thick, were obtained using the particles ranging from 300 to 500 +m, by sintering at 1573 K without applied pressure. The disks had about 35 vol% in porosity and about 10 GPa in Young’s modulus which corresponds to that of human cortical bone. Newly formed bone was observed so as to fill the pore up at 12 weeks, confirming the ability to conduct the ingrowths of the bone tissue. Although in vitro study showed that proliferation of mouse bone marrow stromal ST-2 cells was inhibited on the dishes coated by OCP rather than the control dish, OCP coating on porous Ti seemed to stimulate the bone formation in vivo. Taken together, it seems likely that porous Ti having Young’s modulus similar to bone shows osteoconductive characteristics to conduct bone ingrowths. OCP could be a potential coating agent to assist bone regeneration on porous Ti.