Distribution & Access For Publication Downloads News About Us Contact Us
Paper Titles
Fabrication of Hierarchically Porous Bioactive Glass Ceramics
p.285
Tailoring Mechanical Behavior of PVA-Bioactive Glass Hybrid Foams
p.289
Controlling the Reactivity of Calcium Phosphate Cements
p.295
Parameters Influencing the Properties of Calcium Phosphate Cements
p.299
Calcium Phosphate Cement (CPC): A Critical Development Path
p.303
Effect of Mechanical Mixing and Powder to Liquid Ratio on the Strength and Reliability of a Brushite Bone Cement
p.307
Modifying Brushite Cement Degradation Using Calcium Alginate Beads
p.311
Strength and Chemical Stability Due to Aging of Two Bone Void Filler Materials
p.315
Apatite Foam Fabrication Based on Hydrothermal Reaction of α-Tricalcium Phosphate Foam
p.319

Calcium Phosphate Cement (CPC): A Critical Development Path

Article Preview

Abstract:

The first generation of synthetic bone substitute materials (BSM) was initially investigated in the mid 1970s using hydroxyapatite (HA) as a biomaterial for remodeling of bone defects. The concepts established by CPC pioneers in the early 1980s were used as a platform to initiate a second generation of BSM for commercialization. Since then, advances have been made in composition, performance and manufacturing. A self-setting and injectable calcium phosphate cement (CPC) based on amorphous calcium phosphate (ACP) with calcium to phosphate (Ca/P) atomic ratio less than 1.5, combined with dicalcium phosphate dihydrate (DCPD or brushite, seeded with apatite), is proposed. Amorphization of raw material was observed following high energy mechano-chemical processing. Upon hydration, the cement hardened in less than 3 minutes at 37°C and reached a maximum compressive strength of about 50 MPa. The final product was a low crystalline calcium deficient carbonated apatite similar to the composition and structure of bone mineral. In vivo performance of this cement in mediating bone healing was compared to α-BSM® in a rabbit femoral defect model. Performance characteristics of some commercially available CPC products are compared. The concerns of CPC designers and the needs of product users (surgeons) are discussed.

You might also be interested in these eBooks
Bioceramics 20 View Preview

Info:

Periodical:

Key Engineering Materials (Volumes 361-363)

Pages:

303-306

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.361-363.303

Citation:

Cite this paper

Online since:

November 2007

Authors:

Aliassghar Tofighi, K. Schaffer, R. Palazzolo

Keywords:

Bone Cement, Calcium Phosphate, Characterization, Competitors

Export:

RIS, BibTeX

Price:

Permissions:

Request Permissions

References

[1] Jarcho K. et al., J. Bioeng 1: 79, (1977).

Google Scholar

[2] LeGeros R.Z. et al. J. Dental Res., 61: 343, (1982).

Google Scholar

[3] Brown W.E., Chow L.C., J. Dental Res., 62: 672, (1983).

Google Scholar

[4] Constantz B.R., et al., Science, Vol. 267, pp.1796-1798, (1995).

Google Scholar

[5] Rey C., Tofighi A. et al., Actual. Biomat., Vol. VI, Ed. Romillat, Paris, pp.27-37, (2002).

Google Scholar

[6] Van Landuyt P. et al. Bone, Vol. 25, No. 2, pp. 95s-98s, (1999).

Google Scholar

[7] Chow L.C. et at. J. Res. Natl. Stand. Technolo. 106, pp.1029-1033, (2001).

Google Scholar

[8] Tofighi A. et al., ORS/AAOS, No 1563, p.124, (2007).

Google Scholar

[9] The last Advancement in Bone Substitute Technology, Stryker, USA, (2006).

Google Scholar

[10] Catalano P.J. et al. Key Engineering Materials, Vols. 330-332, pp.799-802, (2007).

Google Scholar

[11] Reddi A.H., The JBJS, Vol. 83-A, Sup. 1, Part 1, pp. S1-1 to S1-6, (2001).

Google Scholar

Scientific.Net is a registered brand of Trans Tech Publications Ltd
© 2024 by Trans Tech Publications Ltd. All Rights Reserved