Release of Growth Factors from Gelatin Microsphere/CaP Composites

W.J.E.M. Habraken; O.C. Boerman; Joop G.C. Wolke; Antonious G. Mikos; John A. Jansen

doi:10.4028/www.scientific.net/KEM.361-363.527

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HomeKey Engineering MaterialsKey Engineering Materials Vols. 361-363Release of Growth Factors from Gelatin...

Release of Growth Factors from Gelatin Microsphere/CaP Composites

Abstract:

Composites of gelatin microspheres and injectable calcium phosphate cement were prepared to increase cement resorption and improve tissue ingrowth. To further enhance these properties, osteoinductive growth factors can be introduced into the microspheres. In this study, the in vitro release of preset gelatin microsphere/CaP composites was followed for 6 weeks by use of 125I-labelled rhBMP-2, rhTGF-β and rh-bFGF. Results for all gelatin microsphere composites showed a release curve that consisted of a small burst, followed by a sustained release. The magnitude of the sustained release was dependent on the growth factor used, and showed a slight dependency on the loading method and type of gelatin. Furthermore, no differences in release pattern or efficiency were found when growth factor concentration increased.

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Periodical:

Key Engineering Materials (Volumes 361-363)

Pages:

527-530

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.361-363.527

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Online since:

November 2007

Authors:

W.J.E.M. Habraken, O.C. Boerman, Joop G.C. Wolke, Antonious G. Mikos, John A. Jansen

Keywords:

Calcium Phosphate Cement (CPC), Drug Release, Gelatin Microspheres, Growth Factor

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