African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2280

Full Length Research Paper

High phenolics and antioxidants of some tropical vegetables related to antibacterial and anticancer activities

Jureerut Daduang1, Sukanda Vichitphan2, Sakda Daduang3, Pranithi Hongsprabhas4 and Patcharee Boonsiri5*    
1Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand. 2Department of Biotechnology, Faculty of Technology, Khon Kaen University, Khon Kaen 40002, Thailand. 3Department of Biochemistry, Faculty of Sciences, Khon Kaen University, Khon Kaen 40002, Thailand. 4Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. 5Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.    
Email: [email protected]

  •  Accepted: 12 May 2011
  •  Published: 31 May 2011

Abstract

Phytochemicals play an important role in the decrease risk of free radicals associated diseases. In the present study, total phenolic contents, antioxidant, antibacterial and anticancer activities of thirty Thai vegetables have been evaluated. The results showed that phenolic contents of Thai vegetables were highly correlated with total antioxidant activities. Four vegetables in strains of Spondias pinnata Kurz., Careya sphaerica Roxb., Caesalpinia mimosoides Lamk. and Cratoxylum Subsp. Pruniflorum (Kurz.) Gogel. with high phenolic contents and total antioxidant activities, have strong antibacterial activities againstStaphylococcus aureusSalmonella typhimurium and Eschericia coli. Although, the extracted samples were non-cytotoxic as confirmed on the normal Vero cells, only C. mimosoides Lamk. extract had inhibitory effect on oral cavity cell line (IC50 27.17 ± 5.44 µg/ml). Thus, this study suggested that some vegetables can be considered as possible therapeutic agents.

 

Key words: Antibacterial, antioxidant, anticancer, phenolic contents, vegetables.