BIOCHEMICAL ACTIVITIES OF THE DERIVATIVES OF DEHYDRODICAFFEIC ACID DILACTONE

YOSHIKI KUMADA; HIROSHI NAGANAWA; TOMIO TAKEUCHI; HAMAO UMEZAWA; KATSUJI YAMASHITA; KIYOSHI WATANABE

doi:10.7164/antibiotics.31.105

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

BIOCHEMICAL ACTIVITIES OF THE DERIVATIVES OF DEHYDRODICAFFEIC ACID DILACTONE

YOSHIKI KUMADA, HIROSHI NAGANAWA, TOMIO TAKEUCHI, HAMAO UMEZAWA, KATSUJI YAMASHITA, KIYOSHI WATANABE

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JOURNAL FREE ACCESS

1978 Volume 31 Issue 2 Pages 105-111

DOI https://doi.org/10.7164/antibiotics.31.105

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Abstract

Activities of derivatives of dehydrodicaffeic acid dilactone (DDCAD) to inhibit catechol-O-methyltransferase (COMT), cyclic AMP phosphodiesterase (PDE) and DOPA decarboxylase(DDC) were examined. Among those tested, 2, 6-bis-(5', 6'-dibromo-4'-hydroxy-3'-methoxyphenyl)-3, 7-dioxabicyclo-[3, 3, 0]-octane 4, 8-dione was found to be the strongestinhibitor of both COMT and PDE. There were no derivatives which showed a strongerinhibition against DDC than the original compound, DDCAD.

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