BBM-928, A NEW ANTITUMOR ANTIBIOTIC COMPLEX I. PRODUCTION, ISOLATION, CHARACTERIZATION AND ANTITUMOR ACTIVITY

HIROAKI OHKUMA; FUMIHIDE SAKAI; YUJI NISHIYAMA; MASARU OHBAYASHI; HIDEYO IMANISHI; MASATAKA KONISHI; TAKEO MIYAKI; HIDEO KOSHIYAMA; HIROSHI KAWAGUCHI

doi:10.7164/antibiotics.33.1087

BBM-928, A NEW ANTITUMOR ANTIBIOTIC COMPLEX

I. PRODUCTION, ISOLATION, CHARACTERIZATION AND ANTITUMOR ACTIVITY

HIROAKI OHKUMA, FUMIHIDE SAKAI, YUJI NISHIYAMA, MASARU OHBAYASHI, HIDEYO IMANISHI, MASATAKA KONISHI, TAKEO MIYAKI, HIDEO KOSHIYAMA, HIROSHI KAWAGUCHI

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JOURNAL FREE ACCESS

1980 Volume 33 Issue 10 Pages 1087-1097

DOI https://doi.org/10.7164/antibiotics.33.1087

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Abstract

A complex of the antitumor antibiotic BBM-928 was produced by an actinomycete strain No. G455-101. Four components, BBM-928 A, B, C and D, were isolated in crystalline form and characterized. They were shown to be cyclic depsipeptide antibiotics containing a quinoline nucleus as the chromophore. BBM-928 A is a monoacetyl derivative of BBM-928 B and a diacetyl derivative of BBM-928 C. BBM-928 components exhibit antimicrobial activity against Gram-positive and acid-fast bacteria. BBM-928 A is highly active in mice against various experimental tumors including leukemia P388, leukemia L1210, melanoma B16, LEWIS lung carcinoma and sarcoma 180. BBM-928 B is less active than BBM-928A, and BBM-928 C has no antitumor activity.

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