STRUCTURE-ACTIVITY RELATIONSHIP OF A NOVEL ANTITUMOR ANSAMYCIN ANTIBIOTIC TRIENOMYCIN A AND RELATED COMPOUNDS

SHINJI FUNAYAMA; YUMI ANRAKU; AKIRA MITA; Zm-Bo YANG; KIYOSHI SHIBATA; KANKI KOMIYAMA; IWAO UMEZAWA; SATOSHI OMURA

doi:10.7164/antibiotics.41.1223

SHINJI FUNAYAMA, YUMI ANRAKU, AKIRA MITA, Zm-Bo YANG, KIYOSHI SHIBATA, KANKI KOMIYAMA, IWAO UMEZAWA, SATOSHI OMURA

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JOURNAL FREE ACCESS

1988 Volume 41 Issue 9 Pages 1223-1230

DOI https://doi.org/10.7164/antibiotics.41.1223

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Abstract

Various derivatives of trienomycin A (1) were prepared and tested for cytocidal activities. All the derivatives except for 22-O-methyltrienomycin A (5) showed reduced cytotoxicity compared with 1. It is concluded that the existence of a triene moiety, free 13-OH and an acyl group at C-11 owe important role for cytocidal activity.

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