STRUCTURAL STUDY OF ISOFLAVONOIDS POSSESSING ANTIOXIDANT ACTIVITY ISOLATED FROM THE FERMENTATION BROTH OF STREPTOMYCES SP.
1989 Volume 42 Issue 9 Pages 1350-1355
Details
1989 Volume 42 Issue 9 Pages 1350-1355
Structures of three antioxidant isoflavonoids isolated from the cultured broth of Streptomyces sp. OH-1049 were shown to be 4', 7, 8-trihydroxyisoflavone (1), 3', 4', 7-trihydroxyisoflavone (2) and 8-chloro-3', 4', 5, 7-tetrahydroxyisoflavone (3), respectively. Among them, 3 is a novel isoflavonoid possessing a chlorine atom in the molecule.
Compound 1 was synthesized and its antitumor activities were tested against IMC carcinoma, SI80, P388 leukemia and P388/ADM leukemia in vivo. As a result, 1 showed 139% increase in life span (ILS) against SI80 bearing mice whereas it showed slight or no ILS against IMC carcinoma, P388 leukemia and P388/ADM leukemia bearing mice.
