REVEROMYCINS, NEW INHIBITORS OF EUKARYOTIC CELL GROWTH II. BIOLOGICAL ACTIVITIES

HIDETOSHI TAKAHASHI; HIROYUKI OSADA; HIROYUKI KOSHINO; MUTSUMI SASAKI; RIE ONOSE; MASAMICHI NAKAKOSHI; MAKOTO YOSHIHAMA; KIYOSHI ISONO

doi:10.7164/antibiotics.45.1414

REVEROMYCINS, NEW INHIBITORS OF EUKARYOTIC CELL GROWTH

II. BIOLOGICAL ACTIVITIES

HIDETOSHI TAKAHASHI, HIROYUKI OSADA, HIROYUKI KOSHINO, MUTSUMI SASAKI, RIE ONOSE, MASAMICHI NAKAKOSHI, MAKOTO YOSHIHAMA, KIYOSHI ISONO

Author information

HIDETOSHI TAKAHASHI
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
HIROYUKI OSADA
Antibiotics Laboratory, RIKEN, The Institute of Physical and Chemical Research
HIROYUKI KOSHINO
Antibiotics Laboratory, RIKEN, The Institute of Physical and Chemical Research
MUTSUMI SASAKI
Antibiotics Laboratory, RIKEN, The Institute of Physical and Chemical Research
RIE ONOSE
Antibiotics Laboratory, RIKEN, The Institute of Physical and Chemical Research
MASAMICHI NAKAKOSHI
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
MAKOTO YOSHIHAMA
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
KIYOSHI ISONO
Antibiotics Laboratory, RIKEN, The Institute of Physical and Chemical Research
Present address: Department of Marine Science, School of Marine Science and Technology, Tokai University

JOURNAL FREE ACCESS

1992 Volume 45 Issue 9 Pages 1414-1419

DOI https://doi.org/10.7164/antibiotics.45.1414

Details

Abstract

Reveromycins A, B, C and D showed inhibitory activity against EGF-stimulated mitogen response in Balb/MK cells. Furthermore reveromycins A, C and D exhibited morphological reversion of src^ts-NRK cells, antiproliferative activity against human tumor cell lines and antifungal activity. The effects of reveromycins A, C and D on eukaryotic cells were closely similar to each other, but those of reveromycin B were very weak. In vitro studies revealed that reveromycin A is a selective inhibitor of protein synthesis in eukaryotic cells.

Corresponding author

Register with J-STAGE for free!