NG-011 AND NG-012, NOVEL POTENTIATORS OF NERVE GROWTH FACTOR I. TAXONOMY, ISOLATION, AND PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

MAYUMI ITO; MASAFUMI MARUHASHI; NORIYOSHI SAKAI; KAZUTOSHI MIZOUE; KAZUNORI HANADA

doi:10.7164/antibiotics.45.1559

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

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Volume 45 (1992) Issue 10
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NG-011 AND NG-012, NOVEL POTENTIATORS OF NERVE GROWTH FACTOR

I. TAXONOMY, ISOLATION, AND PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

MAYUMI ITO, MASAFUMI MARUHASHI, NORIYOSHI SAKAI, KAZUTOSHI MIZOUE, KAZUNORI HANADA

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1992 Volume 45 Issue 10 Pages 1559-1565

DOI https://doi.org/10.7164/antibiotics.45.1559

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Abstract

NG-011 and NG-012, novel potentiators of nerve growth factor (NGF), were isolated from the culture broth of Penicillium verruculosum F-4542, together with 3, 4-dihydro-6, 8-dihydroxy-3-methylisocoumarin. They potentiated the neurite outgrowth induced by NGF in rat pheochromocytoma cell line (PC12).

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